Serotonin

Serotonin (5HT) is a primary monoamine neuromodulator. It is derived from tryptophan.

Location

 * Raphe nuclei are the main source of CNS 5HT

Function

 * 5HT modulates CA1 pyramidal neurons. The initial application hyperpolarizes the cell and raises conductance in both the dendrite and soma. Backpropagating action potentials were affected. Dendrites showed lowered peak potentials while spike amplitude increased in soma. Overall intracellular calcium entry appears to be lower in both locations.