Synaptic scaling

Synaptic scaling is a homeostatic receptor-regulating process by which neurons are believed to maintain stable, functional synaptic weights cell-wide.

Description

 * might be dependent on miR124, which targets and suppresses the expression of GluA2.
 * An RNAseq experiment was carried out and identified genes unregulated during upscaling in cultured neurons with applied TTX.
 * Found that T-type calcium channel activity is required for transcriptional activation
 * Neuronal pentraxin-1 (Nptx1) was necessary for upscaling